I've been playing ampless for years, but this year in particular been doing it live in small shows and a theater venue, and i've never sounded better!
I'm recently comming back from a Fractal AX8 because i've realized that my thing is not very kind on the modelling, i've actually grown tired of emulations, having stomp box sized pres, i'm moving to that, but keeping a door open for having an amp not so loud behind me mostly to not make the sound guys or the venue managers crazy (not many places have a good PA so we still "need it"), and our booking manager as well, because he also puts all the backline. I use an amp only as monitor and sometimes for the audience, but i always use direct for me to feed the in ears mix. I've grown so used to this practice that i don't really miss having an amp, BUT i need a part of the system to be analog, mostly preamp, drives and compression, because to me that's were digital falls short, i even had a phisical problem because of this, altering my playing technique to the point i became at the verge of having tendinitis. So going back to analog pre and drive is a must, also (i believe ) is to simulate as much as you can the power amp response, with eq curves and compression or with some electronic device (as Baja Reactor or PAE pedal) and only leave FX and the speaker response (IR) on the digital domain.