How does it sound outside the enclosure? The metal dc jack might causing some issues. I tend to use plastic just to be safe. The tip solder lug on your IN jack looks very close to the dc jack too. It's hard to tell in this photo, are they touching at all?
How about the other side? I know it's a pain to pull it all out again, but a photo of your joints could help.
I'd also suggest going through the pcb with an audio probe, following the schematic. This should pinpoint exactly where the problem is.