i watched 8 episodes in a row, i loved it. I was impressed by all the tiny details, just like in the game. Rad Away, Stimpacks, the food, etc.
And the great music from the games !
The only difference i noticed is that the Brotherhood of Steel is a bit more evil in the tv show, with some brutal hierarchy that i never saw in the game. And it's a good idea.
The actor playing the ghoul is just great, impressive. The actress playing the main character is good, but kind of average. I'd say the same about Maximus : he does the job quite well but i wont say he is brilliant compared to other actors and actresses in the show.
Each episode is approximately 50 min, but the end credits are super long, like 10 or 15 minutes. That and the quick recap at the beggining of each episodes are cutting a lot of time. I 'd say 1 episode takes 35 minutes really.
Edit : during the whole show, looking at the ghoul make-up was quite disturbing, with this hole instead of a nose, aaaaaah !