as much as i agree how silly this all is, there still is benefit to be had from whatever EQ/tone shaping goes on in an analog unit.
blasting an audio interface with heaps of gain/output to cause ?digital breakup? sounds very silly to me.
...but for what it's worth, i'll often practice songs with the pedalboard -> interface -> DAW (amp sims + IRs), so i can practice quietly without disturbing others.
like everything with DAW/interfaces, it's about setting input levels appropriately.