Depends on the disappear part. If you are running into an already scooped amp, then yes you will. Play a mid heavy guitar like a Les Paul, into a mid heavy amp and the muff balances nicely. Also having a band that understands playing with volume control and dynamics helps- it’s not full out strumming at full volume all the time, and where your parts weave in and out around vocals etc, the Muff can sit very nicely in a mix.Any one which has a modded tone control to be flat or with a sight mid boost. I just hate playing in a band with the stock mid scoop tone control. You disappear.....
(David Gilmour, J Mascis and Billy Corgan had no problem with getting lost).
I do agree though that unless the right condo are met, it is easy to get lost in the mix with one! And I’ve also noticed that fuzzes more than any other pedal are VERY finicky when it comes to guitar/amp combo