I’d personally want to isolate all the jacks. Never know what kind of power supply someone is using, or if they are throwing the preamp of their actual amp in one of the loops. Isolated jacks could keep the grounds to each send/receive pair bussed, but isolated from other pairs. Not a true isolation but likely enough for most situationsGood question! I believe only the MIDI in jack would need to be isolated, right? Unsure though. Maybe the input would be grounded to the box, and the rest of the jacks are isolated?